THE BASIC PRINCIPLES OF SIKIKLER

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Sildenafil is a potent and selective inhibitor of cGMP-certain phosphodiesterase kind five (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular framework of sildenafil is analogous to that of cGMP and functions as being a competitive binding agent of PDE5 during the corpus cavernosum, resulting in extra cGMP